What Depression Does to the Brain
Depression doesn’t just affect your mood, it physically alters your brain’s structure, connectivity, and chemistry. Chronic stress shrinks your hippocampus and prefrontal cortex while enlarging your amygdala, disrupting the circuits that regulate emotion. Heightened MAO-A enzyme activity depletes key neurotransmitters like dopamine and norepinephrine, while neuroinflammation further impairs neural signaling. These changes accelerate brain aging … Read more