Can Depression Make You Sick?

Can Depression Make You Physically Ill?

Depression can be a difficult subject to talk about with others because many people don’t see it as a major health issue. People suffering from depression are sometimes told to simply “snap out of it.” However, depression – especially clinical depression – can do a lot of harm to those suffering, both physically and mentally. And the result, unfortunately, can be suicide. 

What Is Clinical Depression?

Clinical depression is also known as major depressive disorder (MDD), and it is characterized by feelings of hopelessness and sadness. As a result, there is a lack of interest or even pleasure in activities you once enjoyed. While it’s true that people can suffer temporary depression as a result of a loved one passing or other traumatic life events, clinical depression tends to be more severe and can last months or even years. Triggers in life can certainly cause clinical depression, but sometimes, the reasons are rooted in deeply buried traumas. There are some obvious signs when individuals are suffering from MDD.

Therapists usually diagnose you with depression if your intense feelings of despair have been going on for at least two weeks. Many people with depression will lose interest in work, hobbies, and activities they previously enjoyed.

One of the more telling signs of depression is also a change in weight or appetite. There may be significant weight gain or weight loss. Others will suffer from insomnia or may want to sleep all the time, a condition that is called hypersomnia. In addition, mustering up the energy to do anything – even small household chores – becomes painful; even getting out of bed can be a challenge.

There may also be persistent negative thoughts, feelings of worthlessness, and possibly talks of ending it all (suicide). Others may not necessarily talk of suicide, but they may engage in self-harming behavior, such as continuously cutting themselves. 

The signs of depression can be hidden too. Some people put on a cheerful, optimistic exterior that masks deep suffering inside. In cases like these, it can be difficult to tell if someone is suffering from depression. Alternatively, they may soothe their depression with alcohol or drugs. 

As a result, this makes depression tricky to spot. It also makes it difficult to get help for someone struggling with depression as admitting to depression is sometimes misinterpreted as being weak. However, depression is a serious mental health issue that should be attended to immediately once it’s diagnosed. 

What Are the Causes of Depression?

Clinical depression affects both adults and children, and it can be due to a variety of reasons. In fact, it doesn’t have to be just one thing. It can be a combination of factors, such as biological, psychological, and external concerns. 

Biological Factors

An imbalance in your brain chemistry can play a significant role in depression. If you have depleted serotonin and dopamine levels – or what are known as the “happy” chemicals – you can exhibit this deficiency via depression. These chemicals are responsible for regulating your moods and your emotions. The research is still unclear whether the imbalance causes depression or whether depression results in a chemical imbalance. However, the two are linked. 

The structure of your brain could also be associated with depression. The hippocampus regulates mood, and those with abnormalities in the hippocampus may suffer from depression. 

Again, there are many unanswered questions. Do those with chronic depression suffer depression because they have a smaller hippocampus? Or does the hippocampus shrink in individuals suffering from chronic depression? Or is it a little bit of both–or neither?

Another biological factor that plays a role in depression is genetics. Those with a family history of depression have a greater risk of developing depression themselves. A British research team isolated what they call the “depressive gene,” which is chromosome 3p25-26. It was found in 800 patients suffering from clinical depression.

Psychological Factors

Psychological factors can also play a huge role in depression. These factors – typically triggers – could be financial difficulties, losing a loved one, relationship problems, and more. Depression could also develop in those who are striving for a goal and are unable to reach it, such as a failed attempt to qualify for the Olympics or to find success as a musician. This perceived failure can lead to feelings of worthlessness and low self-esteem.

External Factors

There may be external factors that cause depression, too, such as childhood trauma. Childhood experiences can lead to severe instances of clinical depression later in life. They can also lead to substance use disorders. 

Some people may experience depression after suffering debilitating pain from a chronic illness, such as cancer. There are also medications that may list depression as a possible side effect. 

The Mind-Body Connection

The mind-body connection is complicated and multifaceted. The deterioration of one directly affects the other and vice versa. The reverse is also true. When you improve your physical well-being, your mind reacts positively. In other words, your emotional and mental state often have a direct impact on your physical health and well-being. 

Stress

When you experience stress, you activate the stress response in your body, releasing your stress hormones like adrenaline and cortisol. These hormones better equip you so that you can mentally and psychologically handle the stressors in your life. However, if the stressors in your life are constant, you undergo what is called “chronic stress.” This can damage your body in many ways. 

Your immune system can be the first to cave under chronic stress and anxiety. Chronic stress creates conditions where you are more likely to get sick and are slower to recover. Chronic stress can also contribute to cardiovascular problems. Stress hormones increase your heart rate and constrict your blood vessels. Over time, this puts an enormous strain on your heart. Heart failure is often a direct result of chronic stress.

Your digestive system is also disrupted when you suffer chronic stress or anxiety. You may experience indigestion or irritable bowel syndrome (IBS) during highly stressful moments. 

During times of stress, your sleep pattern is disrupted as well. Besides a lack of productivity, a lack of sleep over a period of time can increase your risk for infections. When you sleep, your body releases cytokines, which helps you fight infections. However, when you suffer from sleep deprivation, your body doesn’t have a large enough reserve of cytokines to help ward off infections, such as the common cold. 

Hormonal Changes

Hormonal changes, such as menstrual cycles, have a direct effect on women’s mental health. Some women experience depression with every cycle. Others experience significant mood swings. For some women, the symptoms are mild. For others, the symptoms are severe and are known as premenstrual dysphoric disorder (PMDD).

Hormonal changes appear again during pregnancy and menopause. The physical changes related to pregnancy are due to fluctuations in estrogen and progesterone. While some women are unaffected, others experience depression and anxiety. In menopause, the body makes less estrogen and progesterone, leading to hot flashes, difficulty concentrating, and irritability.

Psychosomatic Symptoms

The mind has incredible control over the body. In some cases, psychological trauma shows up only as chronic pain in the back, neck, or other areas of the body. Often, there is no medical reason. Rather, psychological trauma gets transferred to the body

Some doctors have explained this connection as a continuous tensing up of the muscles. In other words, during psychological trauma, certain muscles in the body continuously tense up. These tensed-up muscles eventually turn into chronic pain. 

Can Depression Make You Sick?

Seeing that the mind and body are so intertwined, it’s only logical to assume that depression can make you sick. If you have been depressed for long periods, you may put your body through equal suffering. 

Affect on the Brain and Hippocampus

One of the more frightening ways that depression can affect you is by damaging your brain. When you experience long-term depression, your brain starts to lose gray matter volume (GMV). This is a result of your hippocampus shrinking. There is also shrinking in the frontal cortex, prefrontal cortex, and thalamus. Eventually, this shrinking can lead to cognitive problems, such as Alzheimer’s disease and Parkinson’s disease.

Digestive Problems

Depression and anxiety often cause irritable bowel syndrome (IBS) or problems with your digestive tract. You may have trouble eating, leading to rapid weight loss. On the other hand, you may eat too much, leading to a rapid weight gain. In both cases, the effect on your weight can be detrimental to your health. 

Weaker Immune System

Because of a change in eating habits and an irritated digestive tract, you may suffer from a weaker immune system. Your body may not be getting the nutrients it needs, especially if your depression is coupled with a drug and alcohol use disorder. 

Cardiovascular Issues

Surprisingly, depression can also increase the risk of heart disease. When you experience long-term depression, your body releases more stress hormones. This, as noted above, can contribute to an increased heart rate, more constricted heart vessels, and an eventual stroke. 

Chronic Pain

Depression can lead to constant headaches, and these constant headaches can – in turn – lead to more depression. There can also be instances of psychosomatic pain, such as unexplained backaches or neckaches. 

Available Treatment Plans for Depression

If you believe you are suffering from depression, it’s essential to get treatment immediately. Treatment plans differ depending on how severe your depression is and what is causing the depression. Here are some treatment plans that have proven to be effective.

Therapy

Different types of therapies are available, and choosing one will simply depend on your preference. 

Cognitive-behavioral therapy (CBT) suggests that your psychological depression is based on a vicious cycle of negative thoughts and behaviors. CBT focuses on developing healthier ways of coping with your depression by changing your thinking patterns. It also teaches individuals how to cope in trying situations. 

Behavioral activation therapy is often used in conjunction with other types of treatments, such as CBT. The goal is to encourage individuals to participate in something meaningful to help improve their mood. By engaging in activities that you once enjoyed, you can create a positive frame of mind.

Another form of therapy that has proven to be effective is interpersonal therapy (IPT). It was originally developed to treat major depressive disorder. IPT is designed to help individuals manage their unresolved trauma or grief. Therapists also help individuals develop skills to better communicate in interpersonal relationships. Much of the focus is on relationship patterns.

Psychodynamic therapy (PDT) comes from Sigmund Freud, and it draws a connecting line between your early childhood experiences and your current frame of mind. The goal of PDT is to allow individuals first to understand their mental health issues and then to take control of those issues. 

Medication

Many people who have been diagnosed with clinical depression combine therapy with medication. Therapy typically takes time before progress becomes apparent, and those suffering from MDD may need something more immediate in the meantime. 

One of the most common types of medications is antidepressants. These interact with neurotransmitters to balance out the individual’s brain chemistry. Ultimately, antidepressants help relieve symptoms of depression.

Serious MDD can result in extreme behavior changes and can even produce psychosis. Medical professionals may prescribe antipsychotic medications and mood stabilizers in addition to antidepressants. 

Healthy Lifestyle Changes

Eating healthier and exercising can often complement therapy and medication. Studies show that regular exercise can boost moods and help with depression. In addition, individuals with MDD are encouraged to sleep roughly seven to eight hours a day and engage in some sort of stress-reducing activity, like yoga or meditation.

National Depression Hotline

If you are suffering from depression, call the National Depression Hotline. We are a phone call away to help get the resources you need. It’s free, confidential, and available 24/7. Call (866) 629-4564 for help.

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Medically Reviewed By:

Robert Gerchalk

Robert is our health care professional reviewer of this website. He worked for many years in mental health and substance abuse facilities in Florida, as well as in home health (medical and psychiatric), and took care of people with medical and addictions problems at The Johns Hopkins Hospital in Baltimore. He has a nursing and business/technology degrees from The Johns Hopkins University.

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